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How the tomato extract, lycopene may help aging, clogged arteries

Tomatoes and other vegetables and fruits contain lycopene. A daily supplement of that lycopene extract found in tomatoes may improve the function of blood vessels in patients with cardiovascular disease, according to new research, "Effects of Oral Lycopene Supplementation on Vascular Function in Patients with Cardiovascular Disease and Healthy Volunteers: A Randomised Controlled Trial," published June 9, 2014 in the journal Plos One.

How the tomato extract, lycopene may help aging, clogged arteries.
Photo by Justin Sullivan/Getty Images

The study's conclusions reported that lycopene supplementation improves endothelial function in cardiovascular disease patients on optimal secondary prevention, but not in healthy volunteers. Also, in other studies, lycopene has been shown to lower the risk of stroke. You may wish to check out the Harvard Health article, "Lycopene-rich tomatoes linked to lower stroke risk," or see the article, "Lycopene May Reduce Your Stroke Risk by 55 Percent."

A tomato 'pill' improves the function of blood vessels in patients with cardiovascular disease, says new research. The latest study reports that a daily supplement of an extract found in tomatoes may improve the function of blood vessels in patients with cardiovascular disease, according to new research from the University of Cambridge.

In a study published in the journal PLOS One, researchers at the University of Cambridge and the Cambridge University Hospitals National Health Service Foundation Trust demonstrate one mechanism by which they believe lycopene reduces the risk. The incidence of cardiovascular disease varies worldwide, but is notably reduced in southern Europe, where a 'Mediterranean diet' consisting of a larger consumption of fruit, vegetables and olive oil predominates. Recent dietary studies suggest that this diet reduces the incidence of events related to the disease, including heart attack and stroke, in patients at high cardiovascular risk, or those who have previously had the disease.

Lycopene from vegetables or fruits, to the rescue?

One component of the Mediterranean diet thought to play a role in reducing this risk is lycopene, a powerful antioxidant which is ten times more potent than vitamin E. Lycopene is found in tomatoes and other fruits, and its potency appears to be enhanced when it is consumed pureed, in ketchup or in the presence of olive oil. Whilst there is strong epidemiological evidence to support the role of lycopene in reducing cardiovascular risk, the mechanism by which it does so is unclear.

If you're not eating tomatoes because, like potatoes and bell peppers, these vegetables come from the nighsthade family that may irritate arthritis in some people, lycopene can be found in other vegetables and fruits in addition to tomatoes. Dr Joseph Cheriyan, consultant clinical pharmacologist and physician at Addenbrooke's Hospital and Associate Lecturer at the University of Cambridge, says, according to the June 9, 2014 news release, 'Tomato pill' improves function of blood vessels in patients with cardiovascular disease, "There's a wealth of research that suggests that the Mediterranean diet – which includes lycopene found in tomatoes and other fruit as a component – is good for our cardiovascular health. But so far, it's been a mystery what the underlying mechanisms could be."

The researchers carried out a randomized, double blind, placebo controlled, interventional trial investigating the effects of lycopene a gold standard method of measuring the function of blood vessels called forearm blood flow, which is predictive of future cardiovascular risk. Thirty-six cardiovascular disease patients and thirty-six healthy volunteers were given either Ateronon (an off-the-shelf supplement containing 7mg of lycopene) or a placebo treatment. As a double blind trial, neither the study participants nor the researchers dispensing the pills were aware which treatment was being provided.

Acetylcholine and having a healthy endothelial function

The patients with cardiovascular disease were all on statins (cholesterol-lowering drugs). However, despite this, they still had a relatively impaired function of the endothelium – the inner lining of blood vessels – compared to healthy volunteers. This function is determined by the response of blood vessels in the forearm to a naturally occurring molecule called acetylcholine. Endothelial function predicts future events, so having a healthy endothelium is an important factor in preventing the evolution of heart disease.

The researchers found that 7mg of oral lycopene supplementation improved and normalized endothelial function in the patients, but not in healthy volunteers. Lycopene improved the widening of the blood vessels by over a half (53%) compared to baseline in those taking the pill after correction for those who took the placebo. Constriction of the blood vessels is one of the key factors that can lead to heart attack and stroke. However, the supplement had no effect on blood pressure, arterial stiffness or levels of lipids.

Lycopene may improve the function of blood vessels in those with cardiovascular disease

"We've shown quite clearly that lycopene improves the function of blood vessels in cardiovascular disease patients," adds Dr Cheriyan , according to the news release. "It reinforces the need for a healthy diet in people at risk from heart disease and stroke. A daily 'tomato pill' is not a substitute for other treatments, but may provide added benefits when taken alongside other medication. However, we cannot answer whether this may reduce heart disease – this would need much larger trials to investigate outcomes more carefully."

Professor Jeremy Pearson, Associate Medical Director at the British Heart Foundation, says, according to the news release, "Impaired endothelial function is a known predictor of increased risk of future heart disease. Further work is needed to understand whether the beneficial effects seen in this small study translate into clinical benefit for at-risk patients."

The study was funded and sponsored by Cambridge University Hospitals NHS Foundation Trust, with further support including the Wellcome Trust, the British Heart Foundation and the National Institute of Health Research Cambridge Comprehensive Biomedical Research Center.

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