A new study from the NIH/National Institute of Allergy and Infectious Disease and the NIH/National Cancer Institute published in the Journal of Clinical Investigation on the health benefits of probiotics shows that these cultures may help people not only with various nasty bacteria and/or virus infections or inflammations, but that probiotics and prebiotics may improve gastrointestinal immunity in animals who are HIV-infected.
In this month's issue of the Journal of Clinical Investigation, you can read how researchers led by Jason Brenchley at the National Institute of Allergy and Infectious Disease, demonstrated that probiotic supplementation improved gut immune function in SIV-infected macaques. Check out the original article "Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques."
If the probiotics helped the monkeys, the question is whether the probiotics and prebiotics also will improve the gut immune function in humans infected with various viruses such as HIV. Antiretroviral (ARV) drugs are the first line therapy for patients with HIV. However, ARV-treated, HIV-infected individuals still have a higher mortality rate than uninfected individuals.
During the course of infection, HIV patients develop inflammation that damages the walls of the intestines, known as the gut mucosa, allowing intestinal microbes to escape and enter the blood stream to cause a life-threatening systemic infection. The health of the gut mucosa is significantly influenced by the complement of bacteria in the gut and there is mounting evidence that probiotic supplements benefit patients intestinal disorders, such as irritable bowel syndrome, C. difficile infection, and inflammatory bowel disease.
In this issue of the Journal of Clinical Investigation, researchers led by Jason Brenchley at the National Institute of Allergy and Infectious Disease, demonstrated that probiotic supplementation may also be beneficial for ARV-treated HIV patients. Brenchley and colleagues treated SIV-infected macaques (a model of human HIV-infection) with either ARV alone or ARV in combination with a mixture of probiotics.
Macaques treated with probiotics had enhanced gastrointestinal immune function and decreased inflammation compared to macaques treated with ARV alone. In a companion article, Judith Aberg and colleagues at New York University School of Medicine discuss how these findings could benefit HIV patients, according to the January 16, 2013 news release, "Could probiotics help HIV patients?"
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