Sacramento consumers would like to know how resveratrol and rapamycin might increase a beneficial fate hormone. How do resveratrol and rapamycin synergistically achieve their results? A new study now explains how a grape ingredient, resveratrol increases a beneficial fat hormone, according to a new study.
At the same time, in the Sacramento-Davis area, UC Davis is looking for participants for a grape seed extract study on the nutritional benefits of products from grape seeds. Check out the UC Davis website for the Grape Seed Extract Study.
Grape Seed Extract Study
Researchers in the UC Davis Department of Nutrition are looking for individuals to determine whether taking grape seed extract prior to eating a high fat meal will reduce the inflammatory response in people with the metabolic syndrome; thereby possibly postponing the diagnosis of diabetes or other chronic inflammatory diseases.
UC Davis needs volunteers who:
- Are over age 21
- Are nonsmokers
- Have high blood pressure and two or more of the following: high waist circumference, high fasting glucose, low HDL cholesterol, and/or high triglyceride levels.
The Study's overview:
- Attend a screening visit to obtain written informed consent and have a blood draw to test for cholesterol levels.
- Attend two 7-hour study visits to our facility. A Registered Nurse will insert a catheter in your arm and take blood once per hour over the course of 7 hours. After the initial blood draw, we will provide you with either a placebo pill or a 300mg grape seed extract pill and a breakfast meal. These visits occur at the CTSC at the Mather VA in Rancho Cordova.
- Keep food records the 3 days prior to the study day; eat a similar evening meal before each study day.
Participants in the study will receive:
- Compensation.
- Results of screening blood work.
For further information and phone numbers, see the UC Davis Grape Seed Extract study's website.
Grape Ingredient, Resveratrol Increases a Beneficial Fat hormone
According to today's January 7, 2011 EurekAlert! news release, Grape ingredient resveratrol increases beneficial fat hormone," Grape ingredient resveratrol increases beneficial fat hormone," resveratrol, a compound in grapes, displays antioxidant and other positive properties. In a study published this week, researchers at the University of Texas Health Science Center at San Antonio describe a novel way in which resveratrol exerts these beneficial health effects.
Check out the university's latest news release on that study at the university's own news site, "Grape ingredient resveratrol increases beneficial fat hormone." Read the abstract of the study which appears in the Jan. 7 2011 issue of the Journal of Biological Chemistry.
Resveratrol stimulates the expression of adiponectin, a hormone derived from cells that manufacture and store fat, the team found. Adiponectin has a wide range of beneficial effects on obesity-related medical complications, senior author Feng Liu, Ph.D., professor of pharmacology and member of the Barshop Institute of Longevity and Aging Studies at the Health Science Center explained in today's news release from the University of Texas Health Science Center at San Antonio.
Both adiponectin and resveratrol display anti-obesity, anti-insulin resistance and anti-aging properties. “Results from these studies should be of interest to those who are obese, diabetic and growing older,” Dr. Liu said in the news release. “The findings should also provide important information on the development of novel therapeutic drugs for the treatment of these diseases.” The researchers confirmed the finding in cells and animal models.
Rapamycin and Resveratrol Studied for Beneficial Health Effects
In July 2009 in the journal Nature, the Barshop Institute and collaborators reported that the compound rapamycin extended life in mice. Rapamycin, like resveratrol, is under scrutiny for its beneficial health effects. Read the abstract of that study on rapamycin. In 2010, Dr. Liu and colleagues announced that resveratrol inhibits activity of the mammalian target of rapamycin (mTOR).
This discovery was included in the prestigious Faculty of 1000 (F1000), a service that identifies and evaluates the most important articles in biology and medical research publications. The selection process involves a peer-nominated global 'faculty' of the world's leading scientists and clinicians who rate the best of the articles they read and explain their importance. A reviewer noted that the study, which appeared in the Journal of Biological Chemistry, would open up work in a new area: explaining how resveratrol and rapamycin synergistically achieve their results.
The University of Texas Health Science Center at San Antonio, one of the country’s leading health sciences universities, ranks in the top 3 percent of all institutions worldwide receiving National Institutes of Health (NIH) funding. Research and other sponsored program activity totaled a record $259 million in fiscal year 2009.
The university’s schools of medicine, nursing, dentistry, health professions and graduate biomedical sciences have produced approximately 26,000 graduates. The $744 million operating budget supports eight campuses in San Antonio, Laredo, Harlingen and Edinburg. For more information on related health and nutrition research, visit The University of Texas Health Science Center.
Sacramento-Davis regional area, UC Davis also focuses on studying how polyphenols work to stop inflammation in the human body
Sacramento consumers might like to know how phytochemicals in fruit such as polyphenols work in the human body to stop inflammation. How limited are researchers' knowledge of what's helpful and what's subtoxic when it comes to taking polyphenols? In the latest study of the health effects of polyphenols, there were concerns with the work on cell uptake of quercetin and resveratrol.
UC Davis studies resveratrol
In the Sacramento area, U.C. Davis also did a study on resveratrol. But in December 2010 another university published a different study on the health effects of resveratrol and quercetin. According to a December 23, 2010 news article from the Boston University Medical Center, "Study on effects of resveratrol and quercetin on inflammation and insulin resistance," this study researched the effects of resveratrol and quercetin on inflammation and insulin resistance. The findings opened up the question of how phytochemicals work in the human body to stop inflammation.
The researchers looked at resveratrol and quercetin from a clinical point of view, to study the role of phytochemicals acting as antioxidants and anti-inflammatory agents. Two years ago, in the Sacramento-Davis area, one of the results of a UC Davis study on resveratrol, a polyphenol, was a reduced incidence of diabetes in the mice studied. In humans, high calorie diets usually mean increased glucose and increased insulin levels that may lead to diabetes or frequent high-glucose (sugar) spikes.
Last Month's Study on How Resveratrol and Quercetin Effect Inflammation and Insulin Resistance at Boston University Medical Center
In a December 2010 study at Boston University Medical Center, (see "Study on effects of resveratrol and quercetin on inflammation and insulin resistance,") primary adipocytes were incubated with the polyphenols, but it is not clear whether or not the concentrations used were subtoxic. So as research continues, would you keep taking your resveratrol and quercetin supplements? Or would you try to get as polyphenols from fruits?
Can resveratrol and quercetin from foods be extremely important in inflammation-associated chronic conditions such as cardiovascular disease, diabetes, and cancer? Quercetin and resveratrol may indeed play an important role in this regard, according to the latest study. These phytochemicals from plants need to be investigated further to establish the clinical importance of natural dietary compounds in the prevention of chronic degenerative conditions.
Researchers carried out the current study to examine the extent to which quercetin and trans-resveratrol (RSV) prevented inflammation or insulin resistance in primary cultures of human adipocytes treated with tumor necrosis factor-a (TNF-a)—an inflammatory cytokine elevated in the plasma and adipose tissue of obese, diabetic individuals.
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