Guerrero's first home run was a solo shot off Edwin Escobar that tied the game 1-1 in the fourth inning. He then smacked a leadoff homer in the sixth inning to ignite a five-run outburst.
The Isotopes (20-23) gave plenty of run support to starter Zach Lee (4-4). The Dodgers prospect allowed two runs on six hits and two walks while striking out a season-high eight batters over six innings of work.
Yimi Garcia and Jose Dominguez then combined for three scoreless innings of relief to sew up the victory over the Grizzlies (21-23). They gave up just one hit while combining for five strikeouts.
Travis Ishikawa's RBI single in the first inning had put Fresno ahead briefly. After Guerrero's home run tied the game in the fourth, Joc Pederson's infield RBI single in the fifth put Albuquerque ahead 2-1.
Following Guerrero's homer in the sixth, Miguel Rojas had an RBI double and Trayvon Robinson scored on a wild pitch. Walter Ibarra and Pederson would each add an RBI single.
Ibarra, Pederson, Robinson and Rojas had two hits apiece for the Isotopes. Giants prospect Edwin Escobar (1-5) gave up five runs on seven hits and three walks in five innings.
Albuquerque will head to Salt Lake to start a four-game series Monday at 6:35 p.m. The Isotopes have not named a starting pitcher, while the Bees will go with lefty Dustin Richardson (0-1, 9.95 ERA).