This sounds like a story from the Onion, but it is actually true. This morning, Gizmodo first reported that a a 67-year-old woman drove for 900 miles over the course of two days this weekend because there was a GPS error. Her destination was only 90 miles away, so the woman didn't have it all up there in the first place.
67-year-old Sabine Moreau started her drive in her home town of Hainault Erquelinnes, Belgium. She wanted to pick up a friend at a train station in Brussels. The station is just 93 miles north from her point of origin. But instead, she turned on her GPS, which told her to drive south, taking her turn by turn all the way down to Zagreb, in Croatia. Instead of a couple hours in the car, she spent a couple days to cover the 900 miles that separates both points in Europe.
I haven't had the best experiences with GPS machines either, though Google Maps on Android is near perfect. I remember driving into one way traffic back in 2007. It goes to show you that a GPS doesn't take the place of a brain, so pay attention!