With the success of The Avengers, Marvel/Disney has raised the bar on comic book movie titles. By no means will I say that the Avengers is the end all do all for comic movies but it opens up a whole new world to the failings of Hollywood to come up with something original.
Adam Warlock - This may be an obscure reference to many non comic fans and would have to overcome the adversity of not being familiar to the general public. But with the introduction of Thanos to the Marvel Cinematic Universe this gives us a chance to expand on Thanos as a major player and show how big a threat he really is. I say use the Jim Starlin story line from the 70's and keep this in space without any ties to earth. While this would be heavily endowed with special effects keep the story rooted to showing how manipulative Thanos really is. Marvel seems to be doing this with the Guardians of the Galaxy and even with the current casting of Vin Diesel and Bradley Cooper to finish out the cast. Warlock could be a good ace in the hole as the secret Vin Diesel Character only because I feel if they are gonna pay him have him flex and act to bring in the women viewers. Plus Adam Warlock is so entwined with the Guardians mythology it seems like a perfect fit.