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Genital herpes vaccine fails clinical trials, GlaxoSmithKline will abandon

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The experimental vaccine known as Simplirix which was designed to block the transmissions of herpes from men to women has failed a major clinical trial that would prevent manufacturing approval. As a result, pharmaceutical giant GlaxoSmithKline has announced they will not pursue any further attempts to develop the vaccine.

The vaccine, Simplirix, was designed to protect against the two major herpes simplex viruses, HSV-1 and HSV-2.

The National Institute of Allergy and Infectious Diseases, which co-sponsored the trial with GlaxoSmithKline, announced Thursday that the vaccine provided no more than 20% protection against infection, a level that was not statistically different from zero. Researchers do not yet know why the vaccine failed.

They are 2 different serotypes that infect humans. HSV type 1 most commonly infects the mouth and lips, causing sores known as fever blisters (95%). It is also an important cause of genital infection.

HSV type 2 is the usual cause of genital herpes, but can also infect the mouth.

Estimates of up to 90% of adults possess antibody against HSV-1. Initial infection with HSV-1 usually occurs before 5 years of age.As far as HSV-2; in the U.S., there are 45-50 million people over 12 years of age infected. HSV-2 antibody occurs in 20-30% of American adults. According to the Centers for Disease Control and Prevention (CDC), HSV-2 is more common in women (about 1 out of 4 women) than men (about one out of eight).

With HSV-1 contact with the virus in saliva of carriers is probably the most important mode of spread.

Most people get HSV-2 by sexual contact with someone who is shedding the virus either during an outbreak or during a period with no symptoms. People who do not know they have herpes play an important role in transmission of the virus.

Both types 1 and 2 may be transmitted to various sites by oral-genital, oral-anal or anal-genital contact. It can also be transmitted by close skin to skin contact.

There is no cure or vaccine available for herpes. There are antivirals that can prevent or shorten outbreaks.

Comments

  • FreeSpeaker 3 years ago

    In a way, this is actually good news. Many of the anti-vax liars like to claim that the outcome of every trial of a new vaccine or drug, by a pharmaceutical company, is guaranteed to show that the vaccine or drug is safe and effectivel Now we have actual proof that this is not so. I would love to know just how much money GlaxoSmithKline spent on this vaccine. While this s wil lnot give the anti-vaxxers a clue, it is a great answer to them.

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  • Anonymous 3 years ago

    Thanks for the article. I'm so disappointed with the results, as I have a loved one suffering from HV2. It is truly a devastating disease. I was hoping this would be successful and am sorry to hear there won't be further development of the vaccine.

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