The 27-year-old Khan (28-3, 19 KOs), who became one of the youngest British titleholders ever at the age of 22, last exited the squared circle in April 2013 after outscoring Mexican Julio Diaz.
Floored by a left hook in the fourth and wobbled by the same punch in the eighth, 10th and 11th rounds, Khan was fortunate to escape without losing to Diaz (40-9-1, 29 KOs).
Meanwhile, the 33-year-old Collazo (35-5, 18 KOs) knocked Victor Ortiz onto Queer Street in January.
Collazo, who has scrapped solid prizefighters Andre Berto, Shane Mosley and Ricky Hatton, is a sneaky southpaw who can fluster any opponent.
Plus, “King Khan” is essentially a glorified chandelier.
Regardless, despite 13 months of inactivity, the more talented Khan should batter Collazo this weekend in “Sin City.”
Ultimately, in a somewhat seesaw affair, expect Amir Khan to earn a late round stoppage over Luis Collazo roughly 72 hours from tonight.