The Australian actor will appear later in the season as Henry Parrish, a kind and reclusive man who possesses supernatural powers that have the potential to help Ichabod Crane (Tom Mison).
The role reunites him with "Sleepy Hollow" executive producers Alex Kurtzman and Bob Orci, who also co-created "Fringe."
He joins "True Blood" star James Frain, who is also joining the series for multiple episodes in the role of Rutledge, a modern-day nobleman who will interrogate Ichabod about his past.
"Sleepy Hollow" debuted to 10.1 million viewers earlier this week, making it Fox's highest-rated fall drama debut in seven years, scoring an impressive 3.5 18-49 rating.
Noble, who played eccentric scientist Walter Bishop for five seasons on "Fringe," will also be reprising his role on "The Good Wife" next season as Matthew Ashbaugh.
"Sleepy Hollow" continues Mondays at 9/8 p.m. CT on Fox. In the second episode, a frightful vision from Ichabod’s former wife, Katrina (Katia Winter), sends him and Lt. Abbie Mills (Nicole Beharie) on the hunt for a vengeful witch from the 1700s, who has been awoken by unknown evils and is on a path of destruction in the quaint town.