Albuquerque (67-63), which has lost seven in a row, is now seven games behind Oklahoma City (74-56) with 14 games left to play this season.
Fife (1-4), making his first start for the Isotopes since July 28, lasted just 34 pitches, only eight of which were strikes.
Trevor Crowe drew a leadoff walk and George Springer was hit by a pitch with one out. Brandon Laird singled to load the bases.
Fife then walked Jonathan Singleton, Jimmy Paredes, Che-Hsuan Lin and Rene Garcia to force in four runs.
Blake Johnson came in and gave up a sacrifice fly to Ruben Sosa and an RBI single to Crowe to make it 6-0. Both runs were charged to Fife.
Albuquerque scored its only runs in the fourth inning on Chili Buss' RBI single and in the fifth on Rusty Ryal's RBI single.
Bobby Doran (2-0) was solid for seven innings, allowing two runs, one earned, on three hits and three walks while striking out three batters.
The Isotopes will wrap up their series with the RedHawks on Tuesday at 6:05 p.m. They will then return home to open a nine-game homestand Wednesday at 6:35 p.m.