Christina Stephens, spokeswoman for the Governor's Office of Homeland Security and Emergency Preparedness, says the figures are "very preliminary," based on an initial assessment of communities with flooding and wind damage.
She says in some areas, flooding limits where damage assessment teams can go and the numbers could rise after FEMA finishes its house-by-house inspections in the hardest-hit parishes.
If the numbers of people who requested FEMA assistance offer a guide, the tally of damaged homes could end up being much higher.
Nearly 95,000 people signed up for individual aid from FEMA, for grants to help repair homes and replace storm-wrecked belongings, according to numbers provided by Gov. Bobby Jindal's office.
The floodwaters were still receding Tuesday in Plaquemines Parish, the hardest hit parish in Louisiana by Isaac.
Plaquemines Parish President Billy Nungesser said there's still a long way to go until all the water is out.
Storm surge flood waters overtopped the local levee system at Barataria Bay and submerged dozens of homes and vehicles under water at the height of the storm.
Isaac is the most significant hurricane to impact the region in four years and or since Hurricane Gustav in 2008.