The star couple have not been seen together since April and rumors of their split intensified in recent weeks leading to the announcement that they had split.
According to sources close to the couple Zeta-Jones was said to have been offended and highly upset over comments Douglas had made about his throat cancer being caused from oral sex. Though Douglas later tried to clarify his statement by saying that he did not get the HPV virus from Zeta-Jones the damage had been done.
Zeta-Jones, 43, has struggled with Bi-Polar II Disorder and has spent time in psychiatric hospitals in April of 2011 and again in April of this year. Douglas, 68, has battled throat cancer which he blamed on the HPV virus that he believes he contracted through oral sex.
There is said to be an "iron-clad" prenuptial agreement if the two do decide to divorce, something Douglas insisted on after giving up $45 million in his divorce to Diandra Luker.
The combination of the health issues and Douglas eldest son Cameron being sentenced to prison until at least 2018 for numerous drug convictions including being caught with drugs while in a correctional facility. Cameron Douglas also had an incident involving another inmate late last year which resulted in his leg being broken.
Douglas and Zeta-Jones have two children together and although they are essentially living separate lives at the moment friends and family are hoping the two will be able to reconcile.
Beyond confirming the split representatives for both have issued no further statement and have asked that their privacy be respected in this difficult time.
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