It was brought to light Wednesday news of researchers in Demark, at The University of Copenhagen, finding a new type of regulatory blood cell that can fight the hyperactivity of T-cells in multiple sclerosis (MS). [see abstract]
T-cells (T lymphocytes) are a type of a white blood cell that has been found to play a central role in bringing about and regulating the “pathophysiology” of MS.
Although some scientists believe MS is more a clinical entity, meaning it is something that breaks off from something else as opposed to being the problem to begin with, researchers at The University of Copenhagen have chosen to look at “the functional changes” of the disease by examining blood cells in mice.
What they found was something no one has ever seen before.
Yawei Liu, associated professor of the studies, had this to say, “We knew that some unidentified blood cells were able to inhibit multiple sclerosis-like disease in mice and through gene analysis we found out, that these cells are a subset of our lymphocytes expressing the gene FoxA1. Importantly, when inserting FoxA1 into normal lymphocytes with gene therapy, we could change them to actively regulate inflammation and inhibit multiple sclerosis.”
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The ‘FoxA1’ mentioned is a class of DNA-binding proteins and it was never known it was the meaning behind lymphocyte development and suppressive functions.
This is very good news considering they can now focus on testing whether the FoxA1-lymphocytes can affect the myelin and “brain degeneration in a model of progressive multiple sclerosis” in mice and, if it holds true to what they believe they have already seen, work at figuring out new therapies for those with progressive forms of MS.
As things stand right now, those with progressive forms of MS don’t have many therapy options and it hasn’t been up until recent years that researchers have spent much time on this type of the disease.
For more info: for those who live in Lima, Ohio, the Northwestern Ohio MS Chapter can be reached at: 401 Tomahawk Drive, Maumee, OH at (419) 897-7263. They are located approximately an hour and a half from Lima, Ohio and 45 minutes from Findlay, Ohio. For directions please click here at Google Maps
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Sources: TY - JOUR, AU - Liu, Yawei, AU - Carlsson, Robert, AU - Comabella, Manuel, AU - Wang, JunYang, AU - Kosicki, Michael, AU - Carrion, Belinda, AU - Hasan, Maruf, AU - Wu, Xudong, AU - Montalban, Xavier, AU - Dziegiel, Morten Hanefeld, AU - Sellebjerg, Finn, AU - Sorensen, Per Soelberg, AU - Helin, Kristian,, AU - Issazadeh-Navikas, Shohreh, TI - FoxA1 directs the lineage and immunosuppressive properties of a novel regulatory T cell population in EAE and MS; JA - Nat Med PY - 2014/02/16/online VL - advance online publication
PB - Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. SN - 1546-170X UR - http://dx.doi.org/10.1038/nm.3485
L3 - 10.1038/nm.3485 M3 - Article http://www.nature.com/nm/journal/vaop/ncurrent/abs/nm.3485.html#supplementary-information; http://www.ncbi.nlm.nih.gov/pubmed/19582415, Severson C, Hafler DA; http://www.medicalnewstoday.com/releases/272749.php