Albuquerque (18-19) fell back below .500, losing the second game of a 12-game road trip. Red Patterson (2-2) was rocked for six runs on seven hits and two walks in four innings. Sam Demel then allowed another three runs in three innings of relief.
Brooks Conrad went deep twice. He hit a two-out, solo home run in the first inning and added a two-run shot in the eighth inning.
In between Conrad's homers, Tyler Greene hit a two-run homer in the fourth inning. Later that frame, Rico Noel smacked a solo shot.
Conrad, Greene and former Isotope Alex Castellanos had three hits apiece. In contrast, Albuquerque mustered just four hits, all singles.
Juan Oramas (3-1) tossed 6.1 scoreless innings, scattering two hits and three walks while striking out five batters. Dennis O'Grady and Hector Ambriz combined for 2.2 scoreless innings.
Dodgers catcher A.J. Ellis began a rehabilitation assignment with the Isotopes on Sunday. He went 1-for-2 with a walk and was caught stealing.
Albuquerque and El Paso (16-21) will meet again Monday at 6:35 p.m. The Isotopes will start right-hander Matt Magill (2-1, 4.94 ERA) against the Chihuahuas' Keyvius Sampson (1-3, 4.05).