Chili Buss hit a solo home run Saturday night to give him an even 100 RBI on the season.
Buss led off the fourth inning with a blast to right field, his 17th of the season.
That lead held until the eighth inning when New Orleans (72-70) finally got to Albuquerque starter Matt Palmer (6-8).
Rob Brantly hit a bloop leadoff single to right and pinch hitter Kyle Jensen drew a walk. Kevin Mattison then dropped down a sacrifice bunt that Palmer fielded and threw to third base, but the throw was wild and went into left field as Brantly scored the tying run.
Onelki Garcia came on in relief and promptly gave up a two-run single to Gil Velazquez.
The Isotopes (74-68) had some fight left in them as they battled former teammate Josh Wall in the ninth inning.
Eliezer Alfonzo ripped a one-out double down the left field line and then Buss reached on a fielding error by first baseman Jordan Brown.
Wall struck out Brian Barden but then walked Justin Sellers to load the bases. The Zephyrs brought in lefty James Leverton to face John Baker, who bats left-handed. Leverton struck out Baker on a called strike three to earn his second save of the season.
Palmer finished with a line of three runs, all earned, on three hits and three walks while striking out eight in seven-plus innings of work to take the loss for Albuquerque.
Arquimedes Caminero (1-0) picked up the victory for New Orleans with two scoreless innings of relief.
The Isotopes and Zephyrs will meet again in the penultimate game of the season Sunday at 5 p.m.
- Reliever Chris Withrow rejoined Albuquerque on Saturday after being sent down by the Dodgers to make room for right-hander Edinson Volquez. Withrow was 4-0 with a 1.78 ERA in 24 games for the Isotopes earlier this season. He will likely rejoin the Dodgers either Sunday when rosters can expand or Tuesday after the Triple-A season ends.
- To make room for Withrow, Angel Castro was placed on the disabled list. Castro had started Friday's game and was technically done for the season anyway with only two games remaining.