Lauren Bodine scored 20 points on 7-9 shooting (6-8 from three point range) to lead the Black Bears.
The River hawks took their only lead of the game when Jasmine McRoy hit a three pointer to give them a 17-16 advantage with 8:28 remaining in the first half.
The Black Bears went on a 17-4 run to take a 33-21 lead. The lead never got lower than seven from that point and got as high as 20.
Cherrish Wallace recorded 18 points, 11 assists, five rebounds, and two steals for the Black Bears.
Ashleigh Roberts scored 18 points and pulled down eight rebounds.
Sigi Koizar came off the bench to record six points, six rebounds, and two assists.
The Black Bears have won four of their last five games.
Maine (10-9/4-2) will host Stony Brook on Sunday afternoon at Cross Insurance Center.
The Black Bears are currently fourth in the America East standings. Stony Brook is 5-1 in conference play and second in the standings.