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Blake Shelton & Shakira will take their 'Medicine' to the ACM Awards

Singer Blake Shelton will perform "Medicine" with Shakira at the 49th Annual Academy of Country Music Awards on Sunday, April 6, 2014.
Singer Blake Shelton will perform "Medicine" with Shakira at the 49th Annual Academy of Country Music Awards on Sunday, April 6, 2014.
Academy of Country Music

Blake Shelton blurs the lines between country and R&B-inflected pop with his appearance on Shakira's latest self-titled record, on a searing ballad titled "Medicine." The duo are set to bring the song to life at this Sunday's 49th Annual Academy of Country Music Awards, as announced on Monday, March 31, via an official press release from the ACM.

Brad Paisley is also teased with a special performance, presumably around what is likely his next single, "River Bank."

They join previously announced performers: Jason Aldean, Luke Bryan, Eric Church, Brett Eldredge, Hunter Hayes, Miranda Lambert, Toby Keith, Justin Moore, Kip Moore, George Strait, Keith Urban, The Band Perry, Florida Georgia Line and Lady Antebellum with legendary musician Stevie Nicks.

The Band Perry are set to open the three-hour live event.

Lambert and Strait will team up together for a Merle Haggard tribute medley, celebrating his lengthy 50-year career in country music. Garth Brooks will present Haggard with the Crystal Milestone award prior to the performance.

Hayes is set to take the stage with his empowering"Invisible" in conjunction with the Child Hunger Ends Here campaign. The ballad is the lead-in to his forthcoming album, Storyline.

More performers and presenters will be announced this week.

Produced by Dick Clark Productions, the awards ceremony (co-hosted by Bryan and Shelton) will be broadcast April 6 on the CBS Network at 8 p.m. EST. Check your local listings for more information.