Currently, Henderson is tied at three with B.J. Penn and Frankie Edgar. However, Henderson can set the record when he takes on Anthony Pettis (16-2 MMA, 3-1 UFC) in the main event of Saturday's UFC 164 event (pay-per-view, 10 p.m. ET) at Bradley Center in Milwaukee.
"My long-term goal is to be the best fighter on the planet, pound-for-pound," Henderson said. "Along the way, you're going to hit other smaller goals, other milestones.
"I always viewed B.J. Penn as the greatest lightweight of all time. I knew he defended his belt three times, so I always had it in my peripheral vision. I knew for me to be where I want to be — breaking Anderson Silva's record — I was going to have to beat B.J.'s along the way."
UFC President Dana White said not many realized the record was up for grabs at UFC 164, but that it's an exciting little tidbit now that people know about it.
"Maybe nobody knew it until I said it," UFC President Dana White said at Thursday's pre-event press conference for UFC 164.
"Sometimes it takes a while," White conceded. "B.J. Penn was this kid who came into the UFC as a jiujitsu guy, and he just started knocking people out. He was explosive. He was athletic. He was freaky, and he was a maniac. Some guys burst onto the scene like a Conor McGregor, and everybody's talking about him because he's got that thing, and other guys take a little while (longer). Believe it or not, it took a long time before anybody gave a s--t."
Henderson (19-2 MMA, 7-0 UFC) and Pettis meet on Aug. 31 in the main event of UFC 164.