The airline applied for permission from the U.S. Department of Transportation and the Mexico Direccion General de Aeronautica Civil to start service on Nov. 6.
"As Seattle's leading airline, we're committed to offering the most nonstop service to the popular destinations our customers want to explore, including leisure hotspots like Cancun," Joe Sprague, Alaska's vice president of marketing, said in the news release. "Customers taking Alaska Airlines' flight to Cancun will enjoy our award-winning service and low fares."
Alaska Airlines previously flew to Cancun and cancelled flights in 2010. Cancun is the latest destination announced by Alaska Airlines from Seattle. Other new destinations include: New Orleans, Tampa, Detroit, Baltimore and Albuquerque.