Charles Brewer (5-9) was dominant for the first eight innings for Reno (58-52), scattering three hits, walking none and striking out five. Will Harris gave up a hit and a walk in the ninth but struck out two to finish it.
Albuquerque (52-58) got doubles from Tim Federowicz and Clint Robinson. Alex Guerrero and Mike Baxter each had a single.
The Aces scored all the runs they would need in the fifth inning. Mike Freeman hit a leadoff double, Bobby Wilson singled and Ronny Cedeno drew a walk to load the bases.
Brewer then helped his own cause with a three-run double to right field. Those were his first three RBI of the season.
Roger Kieschnick added an RBI double that scored Brewer. Aaron Cunningham and Freeman later added RBI singles to cap all the scoring in the game.
New Isotope Barry Enright (0-1) took the loss, allowing all six runs in 4.2 innings of work. He gave up nine hits and two walks while striking out only one batter.
Enright was signed as a free agent by the Dodgers and assigned to Albuquerque. The 28-year-old right-hander has logged 148.2 innings in the Major Leagues with the Diamondbacks and Angels, though he had spent all of this year struggling (4-9, 5.58 ERA) at Triple-A Lehigh Valley (Phillies).
Overall, Enright has gone 7-13 with a 5.57 ERA in the Majors. The former Pepperdine standout was a second-round pick of Arizona in 2007.
The Isotopes will head to Sacramento to open a four-game series Tuesday at 8:05 p.m. Right-hander Red Patterson (3-7, 5.68 ERA) will start for Albuquerque against River Cats lefty Tommy Milone (1-0, 5.40).
Prior to the game, the Pacific Coast League announced the suspensions for the Isotopes involved in Saturday's brawl with the Aces. Pitcher Carlos Frias got seven games, pitchers Pedro Baez and Jose Dominguez got four games while pitcher Yimi Garcia and infielder Walter Ibarra each got three games. Ibarra and Frias began serving their suspensions immediately, while the other pitchers will follow Frias in order of Dominguez, Baez and Garcia. ... No suspension was announced for infielder Erisbel Arruebarrena, who was activated from his rehab assignment by the Dodgers on Sunday and optioned to Single-A Rancho Cucamonga. He is expected to be suspended once the logistics are worked out.