First up will be Melbourne Victory who will face a playoff against Thailand's Muangthong United, India's Pune or Vietnam's Hanaoi T&T for a place in Group G.
Pune and Hanaoi are yet to playoff in the initial round before facing up to Muangthong and the venue for that final playoff is yet to be decided with Victory the probable host.
Victory would do well not to underestimate their playoff opponents and learn from the mistake of Brisbane Roar in 2013 who had to face a playoff in Thailand but fell on penalties in tough conditions.
A very tough reward would await Melbourne Victory should they advance to the main round as they would face the Japanese Emperor's Cup winners, Jeonbuk Motors of Korea and the 2013 Champions, China's Guangzhou Evergrande.
The Premiers and debutants, Western Sydney Wanderers will meet Chinese side Guizhou Renhe, Korean side Ulsan Hyundai and Japan's second choice side, which will be either Kawasaki Frontale or Yokohama F Marinos, depending on who wins the Emperors Cup.
The Mariners may actually have it a little easier in 2014 than their 2013 edition which saw them advance to the Round of 16.
It could be a match against China's Beijing Guoan as they play the other third playoff round match against either Thai side Chonburi who will host the second round playoff against the winner of Singapore's Tampines Rovers and South China, from Hong Kong who play in the opening round.
The Mariners' two other opponents will be from the K-League, FC Seoul, and the J-League champions, Sanfrecce Hiroshima in what is sure to be a tough match.
As always a big concern for the A-League clubs will be what matches are around the A-League Finals and, of course, there's going to be big conflicts.
With the A-League Grand Final slated for the 4th of May it will be the last two rounds of the group stages that have an impact on playoffs.
Melbourne Victory certainly have the worst draw coming in to the A-League Finals as they will face a trip to Korea for their match against Jeonbuk before playing the defending Champions, Guangzhou in a home match the week before the Grand Final.
Western Sydney also have a tough line up as they'll fly to Japan for their away match before hosting Ulsan right before the Grand Final.
For the Mariners it's also tough as they play Seoul at home before playing the J-League champions on the road in Hiroshima right before the Grand Final.