Albuquerque (55-65) brought in lefty Scott Elbert (0-1) to pitch the eighth inning. Matt Reynolds, Allan Dykstra and Andrew Brown each singled to load the bases.
Brandon Allen's RBI single brought Las Vegas (67-54) within one run. Two batters later, Taylor Teagarden's bloop single drove in the tying run.
Robert Carson was then brought in with the bases loaded and one out. He did not fare any better than Elbert, giving up an RBI groundout to Anthony Seratelli and a two-run double to Daniel Muno.
Alex Guerrero singled with one out in the ninth, but was left stranded. Gonzalez German earned his fourth save.
Joc Pederson went 3-for-4 with a two-run homer in the first inning for the Isotopes. Tim Federowicz was 3-for-4 with a solo home run and three RBI total.
Darwin Barney, playing shortstop, was 2-for-4 with a double and three runs scored out of the lineup. No one else in the Albuquerque lineup had more than one hit.
Barry Enright started for the Isotopes, allowing four runs on six hits and two walks in 4.2 innings. John Lannan gave up four runs on nine hits and three walks in four innings for the 51s.
Chase Bradford (2-1) picked up the victory with a scoreless eighth inning. He struck out two and allowed one hit.
Albuquerque and Las Vegas will meet again Saturday at 8:05 p.m. Lefty prospect Chris Reed will make his Triple-A debut for the Isotopes against 51s right-hander Cory Mazzoni (2-1, 4.43 ERA).