The 49ers will rest a good portion starting players, according to Cam Inman. Eric Reid, Ahmad Brooks, Tarell Brown, Donte Whitner, Carlos Rogers, Aldon Smith, Justin Smith, Ray McDonald, Patrick Willis and NaVorro Bowman will not be playing for the night, leaving Ian Williams as the only starter playing on defense.
Offensive starters who did not participate in practice include Kyle Williams and Anquan Boldin.
Meanwhile, Seneca Wallace is not in uniform tonight as the 49ers plan to release him soon, according to Matt Barrows. Only Colin Kaepernick, Colt McCoy and B.J. Daniels are the only quarterbacks suited up. While there are roster battles ongoing in the final preseason game, the quarterback position will not be one of them.
Wallace was signed by the 49ers last week which made others think Colt McCoy and then backup QB Scott Tolzien were in trouble. McCoy restructured his contract earlier this week and was declared the No. 2 quarterback head coach Jim Harbaugh immediately after Sunday's exhibition against Minnesota.
All NFL teams must trim their roster from 75 to 53 by Saturday. The 49ers have had three quarterbacks on the roster in both of Harbaugh’s two seasons as team's head coach.