LaMichael James sprained his knee in the last preseason game and is inactive for the first game against the Packers. Other 49ers inactives include WRs Chris Harper and Jon Baldwin, G Joe Looney, DL Will Tukuafu, LB Nate Stupar and QB B.J. Daniels.
The 49ers are playing four WRs for this game, including Kyle Williams who makes his return for the first time since November 25.
For the Packers, the inactives are CB Casey Hayward, S Morgan Burnett, LB Nate Palmer, LB Sam Barrington, G Lane Taylor, TE Brandon Bostick and DE Josh Boyd. Hayward was ruled out for the game earlier this week while Burnett (hamstring) was initially questionable. S Jerron McMillan will start in Burnett's place.