Six people were injured, and Interstate 97 was closed for three hours, delaying school buses and snarling Memorial Day weekend traffic.
A FedEx tractor-trailer, a pickup truck, a minivan and two other cars collided at 11:28 a.m. at Interstate 97 and Route 100, police and firefighters said.
Firefighters had to extricate the pregnant woman, 35, from her van before she was flown to Maryland Shock Trauma Center, where she underwent an emergency Cesarean section, state police and firefighters said.
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After delivery, the baby took a few breaths and died, police said.
One man was in serious condition, while five others were treated for minor injuries.
Police did not immediately identify the victims.
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