National Semiconductor Corp. (NSM) also fell more than 5.4 percent, while Sunnyvale-based Yahoo Inc. (YHOO) rose more than 1.9 percent and South San Francisco-based Genentech Inc. (DNA) rose 0.4 percent.
The markets closed down overall, with the Dow Jones down more than 1.6 percent, the Nasdaq more than 1.6 percent and the S&P 500 down more than 1.4 percent.
Local companies in the news included SanDisk Corp. (SNDK), which introduced a new flash storage drive Wednesday.
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